An efficient preparation of labelling precursor of [11C]L-deprenyl-D2 and automated radiosynthesis

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An efficient preparation of labelling precursor of [11C]L-deprenyl-D2 and automated radiosynthesis

Background The synthesis of [11C]L-deprenyl-D2 for imaging of astrocytosis with positron emission tomography (PET) in neurodegenerative diseases has been previously reported. [11C]L-deprenyl-D2 radiosynthesis requires a precursor, L-nordeprenyl-D2, which has been previously synthesized from L-amphetamine as starting material with low overall yields. Here, we present an efficient synthesis of L-...

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ژورنال

عنوان ژورنال: EJNMMI Radiopharmacy and Chemistry

سال: 2017

ISSN: 2365-421X

DOI: 10.1186/s41181-017-0029-5